Splice (2009)

Splice is a 2009 Canadian/American/French science fiction horror film directed by Vincenzo Natali and starring Adrien Brody and Sarah Polley, who portray a young scientist couple, choosing to introduce human DNA into their work of splicing animal genes.

Genetic engineers Clive Nicoli (Adrien Brody) and Elsa Kast (Sarah Polley) hope to achieve fame by successfully splicing together the DNA of different animals to create new hybrid animals for medical use. After creating a female version of one of their creations, they want to use human DNA in a hybrid that could revolutionize science and medicine, but are forbidden by the pharmaceutical company that funds their research, N.E.R.D. (Nucleic Exchange Research and Development), instead mandating that their department be re-organized to focus on finding and extracting certain proteins from the creatures they have already created. Secretly, Clive and Elsa conduct their own experiments, blending human DNA with that of other animals. Though they disagree about actually bringing the hybrid to full term, Elsa pushes the issue and persuades Clive to go along with it, in continued secrecy. They name their creature Dren ("nerd" backwards- because Elsa refuses to refer to her as a "specimen") who exceeds their expectations; she grows and learns at an accelerated rate. As their lab becomes more and more crowded and the risk of Dren being discovered increases, they move Dren to Elsa's late mother's farm. Unbeknownst to Clive and Elsa, one of the original female hybrid animals that they had created changes sex, leading the two to kill each other during a company meeting. Elsa, who had previously formed a maternal bond with Dren, changes her mind after Dren exhibits violent behavior, killing a pet cat out of spite and then assaulting Elsa. She cuts off Dren's stinger and uses tissue samples from it to finally isolate and synthesize the protein they had been searching for. Soon after, Dren jumps naked on Clive and the two eventually have sex. They are discovered by Elsa and they have a heated argument. During the row he confronts her about having used her own egg in the creation of Dren. Deciding to deal with Dren (terminate the experiment, and presumably Dren's life), they go back to the farm, only to discover her dying. Shortly afterwards their boss from the pharmaceutical company arrives with Clive's younger brother Gavin. Gavin is aware of Dren's existence and has confirmed Barlow's suspicions that some sort of human hybrid has been created (due to the DNA present in the new protein they synthesized). They are attacked by Dren, who was not dead and is now male. Dren kills Gavin and the boss, harms Clive, finds Elsa and rapes her. As Dren is raping Elsa, Clive attempts to kill Dren, but is killed in the process. Elsa then kills Dren. Later on, Elsa is seen in an office and is given a massive amount of money in exchange for her silence over Dren and taking the experiment to the "next stage". Elsa stands up and is revealed to be pregnant, saying "What's the worst that could happen?"